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Isobe, Minoru
Title： NSC Chair Professor

Education：

Nagoya University (Japan) (Ph.D.) (1973)
Nagoya University (Japan) (M.S.) (1969)
Nagoya University (Japan) (B.S.) (1967)
Office： Chemistry Building R702
Phone number： 35608
E-mail： minoru@mx.nthu.edu.tw
Web site： will update

Work Experience：

Instructor of Nagoya University (Japan) 1970 ~ 1975
Postdoctoral Research, Columbia University (USA) 1973 ~ 1975
Associate Professor of Nagoya University (Japan) 1975 ~ 1991
Professor of Nagoya University, Bioagricultural Sciences (Japan) 1991 ~ 2008
Professor Institute of Advanced Research (Japan) 2005 ~ 2009 
Professor Emeritus of Nagoya University (Japan) 2008 ~ present 
NSC Chair Professor, National Tsing Hua University (Taiwan) 2008 ~ present

Visiting Professors：

Iowa State University, Chemistry Department, Ames, Iowa, US (November-December, 1981).
Nijmegen University, Dept. Organic Chem., Nijmegen, The Netherlands (July-August, 1986).
Londrina University, Londrina, Parana, Brazil (March 1991).
Université de Paris-Sud, Institut de Chimie Moléculaire d'Orsay, France (Sept.-Oct., 1992).
Mahidol University, Bangkok, Thailand (August  1993).
Invited Professor, Amsterdam Univ., Dept. Organic Chem., Netherland (August-September, 2001).

Editors：

Chemistry Letters; JCS 1989 ~ 1992
B. B. B. Nihon Nougei Kagaku Kai 1998 ~ 2002
Chemistry, an Asian Journal  2006 ~ present 

Members：

Coordinator of JSPS-ACP (Asian Core Program = Cutting-Edge Organic Chemistry in Asia) (2005.10-2008.3); International Advisory Board (2008-present).

IUPAC Titular Member of Organic Division (2002-2007).

IUPAC Division President of Organic & Biomolecular Chemistry (2004-2007);
Past President (2008-2009).

IUPAC Task Group Chair of Project #2011-041-1-300 “Strategic Planning for a new South East Asian Network for Organic Chemistry (2005-present).

Associate Member, Science Council of Japan (2006-2011, Division IUPAC).

Award：

Young Chemists Award, Agricultural Chemical Society of Japan (1986) "Stereocontrolled Syntheses of Complex Bioactive Natural Products"

Award from Japan Society of Organic Synthesis (1996) "Stereocontrolled Synthesis of Multi-stereogenic and Bioactive Compounds"

Award from the Agricultural Chemical Society of Japan (2000) "Bioorganic Studies on Chemical Communication in Biological System" (name changed to Japan Society for Bioscience, Biotechnology, and Agrochemistry)

SIMM Professor Emeritus (Shanghai Institute of Material Medica: 2007.5.22)

Nagoya University Professor Emeritus (2008.4)

Medal with Purple Ribbon (紫綬褒賞) from the Emperor of Japan (2008.5.16)

Research Areas：

Organic Chemistry、Natural Product Chemistry、Bioorganic Chemistry

  1. Total Synthesis with Stereochemical Control (vernolepin, maytansine, okadaic acid, tautomycin, tetrodotoxin, ciguatoxin etc.).
     
  2. Bioluminescence (coelenterate, mushroom, squid, millipede etc., molecular mechanism on luminescence of photoprotein).
     
  3. Marine Chemistry (ciguatoxin, tetrodotoxin etc. inhibitors of sodium channel, or protein phosphatase), (photoproteins from squid).
     
  4. Insect Hormone (diapause hormone, molecular mechanism on termination of diapause, Time Interval Measurement Protein = Timer Protein).
     
  5. Ion selective ionophore (higher structure of cereulide).
     
  6. Chemistry for biology (molecular interaction between natural product and target protein).


List of Publicatioin：(2006 ~ 2012)

284.  Convergent Synthesis of the Right-Hand Segment of Ciguatoxin.  Hamajima, A.; Isobe, M. Org. Lett. 2006, 8(#6), 1205-1208.

285.  Synthesis of b-analogues of C-mannosyltryptophan, a novel C-glycosylamino acid found in proteins. Nishikawa, T.; Koide, Y.; Kanakubo, A.; Yoshimura. H.; Isobe, M. Org. Biol. Chem. 2006, 4, 1268-1277.

286.  Synthesis of Urea-Tethered Neoglycoconjugates and Pseudooligosaccharides in Water.  Ichikawa, Y.; Matsukawa, Y.; Isobe, M.  J. Am. Chem. Soc. 2006, 128(#12), 3934-3938.

287.  Novel Functional Group Transformation from Acetylene Cobalt Complex to Ketone via Ligand Exchange.  Hamajima, A.; Nakata, H.; Goto, M.; Isobe, M.  Chem. Lett. 2006, 35(#4), 464-465.

288.  An Efficient Total Synthesis of Optically Active Tetrodotoxin from Levoglucosenone.  Urabe, D.; Nishikawa, T.; Isobe, M.  Chem. Asian J. 2006, 1-2, 125-135.

289.  The Molecular Mechanism of the Termination of Insect Diapause, Part 1: A Timer Protein, TIME-EA4, in the Diapause Eggs of the Silkworm Bombyx mori is a Metallo-Glycoprotein. Isobe, M.; Kai, H.; Kurahashi, T.; Suwan, S.; Pitchayawasin-T. S.; Franz, T.; Tani, N.; Higashi, K.; Nishida, H.  Chem BioChem. 2006, 7, 1590-1598.

290.  Biological Activity of the Functional Epitope of Ciguatoxin Fragment AB on the Neuroblastoma Sodium Channel in Tissue Culture.  Hokama, Y.; Chun, K. E.; Campora, C. E.; Higa, N.; Suma, C.; Hamajima, A.; Isobe, M.  J. Clinical Laboratory Analysis  2006, 20, 126-132.

291.  One-pot transformation of trichloroacetamide into readily deprotectable carbamates.  Nishikawa, T.; Urabe, D.; Tomita, M.; Tsujimoto, T.; Iwabuchi, T.; Isobe, M.  Org. Lett. 2006, 8, 3263-3265.

292.  Antifungal Azaphilones from the Fungus Chaetomium cupreum CC3003. Kanokmedhakul,S.; Kanokmedhakul,K.; Nasomjai,P.; Louangsysouphanh,S.;  Soytong,K.; Isobe,M.; Kongsaeree, P.; Prabpai, S.; Suksamrarn,A.  J. Nat. Prod. 2006, 69, 891-895.

293.  Time-measurement-regulating peptide PIN may alter a timer conformation of Time Interval Measuring Enzyme (TIME).  Ti, Xiaonan; Tani N.; Isobe, M.; Kai, H.  J. Insect Physiology 2006, 52, 461-467.

294.  Syntheses of Naturally Occurring Terphenyls and Its Related Compounds. Sawayama, Y.; Tsujimoto, T.; Sugino, K.; Nishikawa, T.; Isobe,M.; Kawagishi, H. Biosci. Biotech. Biochem. 2006, 70(#12), 2998-3003.

295.  Molecular Diversity of Valinomycin, a 36-Membered Cyclic Depsipeptide, Which was Detected by Means of HPLC-Q-TOF-MS on Hydrolysate Dipeptides. Pitchayawasin-Thapphasaraphong,S.;  Isobe, M.  ITE Letters on Batteries, New Technologies & Medicine 2006, 7, 465-473.

296.  Synthesis of Urea-Tethered Disaccharides in Water.  Ichikawa, Y.; Matsukawa, Y.; Tamura, M.; Ohara, F.; Isobe, M.; Kotsuki H. Chem. Asian J. 2006, 1, 717-723.

297.  Synthesis of b-analogues of C-mannosyltryptophan, a novel C-glycosylamino acid found in proteins.  Nishikawa, T.; Koide, Y.; Kanakubo, A.; Yoshimura, H.; Isobe, M.  Org. Biomol. Chem. 2006, 4, 1268-1277.

298.  Stereocontrolled Route to Vicinal Diamines by[3.3] Sigmatropic Rearrangement of Allyl Cyanate: Asymmetric Synthesis of anti-(2R,3R)-and syn-(2R,3S)-2,3-Diaminobutanoic Acids.Ichikawa, Y.; Egawa, H.; Ito, T.; Isobe, M.; Nakano, K.; Kotsuki, H. Org. Lett. 2006, 8(#25), 5737-5740.

299.  Malyngamide X: The First (7R)-Lyngbic Acid that Connectts to a New Tripeptide Backbone from the Thai Sea Hare Bursatella leachii.   Suntornchashwej, S.; Suwanborirux, K.; Koga, K.; Isobe, M.  Chem. Asian J. 2007, 2, 114-122.

300.  Synthesis of [18,19,21,22-13C4]-Labeled Tautomycin as an NMR probe of protein phosphatase inhibitor. Isobe, M.; Kurono, M.; Tsuboi, K.; Takai, A. Chem. Asia J. 2007, 2, 377-385.

301.  Geldanamycin derivatives and neuroprotective Effect on Cultured P19-derived neurons.  Sarin Tadtong,S.; Meksuriyen, D.; Tanasupawat,S.;  Isobe,M.; Suwanborirux. K.  Bioorg. Med. Chem. Lett. 2007, 17, 2939-2943.

302.  Total synthesis of malyngamide X and its 7’S-epi-Isomer. Suntornchashwej, S.; Suwanborirux, K.; Isobe, M. Tetrahedron 2007, 63, 3217-3226.

303.  Synthesis of the second generation photoaffinity probes of tautomycin. Sydnes, M. O.; Isobe, M. Tetrahedron 2007, 63, 2593-2603.

304.  Synthesis of Symmetric HIJ-ring model of Ciguatoxin.  Nonomiya, A.; Hamajima, A.; Isobe, M. Tetrahedron 2007, 63, 5886-5894.

305.  Determination of Solvent-Trapped Products Obtained by Photolysis of Aryl Azides in 2,2,2-Trifluoroethanol.  Sydnes, M. O.; Doi, I.; Ohishi, A.; Kuse, M.; Isobe, M.  Chem. Asian J., 2007, 3, 102-112.

306.  Protein Phosphatase Inhibitory Activity of Tautomycin Photoaffinity Probes Evaluated at Femto-molar Level.  Magne O. Sydnes, Masaki Kuse, Masakuni Kurono, Aya Shimomura, Hiroshi Ohinata, Akira Takai and Minoru Isobe, Bioorg. Med. Chem. 2008, 16, 1747-1755.

307.  Synthesis of N-Hydroxyenamide, a potential precursor of chartelline.  Kajii, S.; Nishikawa, T.; Isobe, M.  Tetrahedron Lett., 2008, 49, 594-597.

308.  One-Pot Reductive Monoalkylation of Nitro Aryls with Hydrogen over Pd/C. Sydnes, M.O.; Isobe, M.  Tetrahedron Lett., 2008, 49, 1199-1202.

309.  Reductive monoalkylation of nitro aryls in one-pot.  Sydnes, M. O.; Kuse, M.; Isobe, M. Tetrahedron, 2008, 64, 6406-6414.

310.  Synthetic Studies and biosynthetic considerations on marine alkaroid chartelline.  Nishikawa, T.; Kajii, Isobe, Chem. Communic. 2008, 3121-3123.

311.  Cysteine 390 is the binding site of luminous substance with symplectin, a photoprotein of Okinawan luminous squid, Symplectoteuthis oualaniensis. Isobe, M.; Kuse, M.; Tani, N.; Fujii, T.; Matsuda, T. Proc. Jpn. Acad., Ser. B. 2008, 84, 386-392.

312.  Regioselectivity of Larock indol synthesis using functionalized alkynes. Sugino, K.; Yoshimura, H.; Nishikawa, T.; Isobe, M. Biosci. Biotech. Biochem. 2008, 72, 2092-2102.

313.  Development of an Enzyme-Linked Immunosorbent Assay for the Detection of Ciguatoxin in Fish Tissue Using Chicken Immunoglobulin Y.  Campora, C. E.; Hokama, Y.; Yabusaki, K.; Isobe, M. J. Clin. Lab. Anal. 2008, 22, 239-245. 

314.  Syntheses of N-Acylisoxazolidine Derivatives, related to a partial structure found in Zetekitoxin AB, a golden frog poison. Nishikawa, T.; Urabe, D.; Isobe, M.  Heterocycles, 2009, 79, 379-385.

315.  Differentiation of Coelenteramide Sulfates from Phosphates by means of Hydrogen/Deuterium Exchange with Ion Trap Mass Spectrometry. Doi, I.; Kuse, M.; Nakashima, Y.; Tani, N.; Isobe, M. Journal of the Mass Spectrometry Society of Japan (JMSS), 2009, 57, 89-95.

316.  Total Synthesis of Ciguatoxin. Hamajima, A.; Isobe, M. Angew. Chem. Int. Ed. 2009, 48, 2941-2945.

317.  Higher Structure of Cereulide, an emetic toxin from Bacillus cereus, with special comparison with Valinomycin, an antibiotic from Streptomyces fulvissimus. Makarasen, A.; Yoza, K.; Isobe, M. Chem. Asian J. 2009, 4, 688-698.

318.  Novel Stereocontrolled Synthesis of Highly functionalized Cyclobutanes by Epoxide Opening through a Carbanion Intermediate in Heteroconjugate Addition. Adachi, M.; Yamauchi, E.; Komada, T.; Isobe, M. Synlett. 2009, 1157-1161.

319.  Molecular Heterogeneity of TIME-EA4, a Timer Protein in Silkworm Diapause Eggs. Suthasinee Pitchayawasin-Thapphasaraphong, Naoki Tani, Minoru Isobe, Hidenori Kai, Takuya Kurahashi, Junko Kato, Saikwan Trisunan, Biosci. Biotechnol. Biochem., 2009, 73, 1578-1585.

320.  Synthesis of four Lysine-linked cereulide analogs showing K+ ionophoric activity as lead compounds for emetic toxin-detection by immunoassays. Makarasen, A.; Nishikawa, T.; Isobe, M. Synthesis, 2009, (#13) 2184-2194.

321.  1H NMR Aided Elucidation of Products Derived from Photodegradation of Ethyl 3-azido-4,6-difluorobenzoate in 2,2,2-Trifluoroethanol. Sydnes, M. O.; Kuse, M.; Doi, I.; Isobe, M. Tetrahedron, 2009, 65, 3863-3870.

322.  Selective protein modification by the hydroperoxide intermediate in a photoprotein, aequorin. Issei Doi, Masaki Kuse, Toshio Nishikwa and Minoru Isobe, Bioorg. Med. Chem., 2009, 17, 3399-3404.

323.  Substituent effect of imino-O-arenesulfonates, a coupling partner in Suzuki-Miyaura Reaction for substitution of the Pyrazine Ring: A Study for the Synthesis of Coelenterazine Analogs. Makarasen, A.; Kuse, M.; Nishikwa, T.; Isobe, M. Bull. Chem. Soc. Jpn 2009, 82, 870-878.

324.  A relaxin-like peptide purified from radial nerves induces oocyte maturation and ovulation in starfish, Asterina pectinifera.  Masatoshi Mita*†, Michiyasu Yoshikuni‡¶, Kaoru Ohno‡, Yasushi Shibata‡, Bindhu Paul-Prasanth‡, Suthasinee Pitchayawasin§, Minoru Isobe§, and Yoshitaka Nagahama, Proc. National Academy of Sciences, 2009, 106, 9507-9512.

325.  Oxidatively Induced Cu for Mn Exchange in Protein Phosphatase 1g: A New Method for Active Site Analysis.  Miyazaki, A.; Sydnes, M. O.; Isobe, M.; Ohinata, H.; Miyazu, M.; Takai, A.  Bioorganic Med. Chem., 2009, 17, 7978-7986.

326.  Prevention of Copper-Induced Calcium Influx and Cell Death by Prion-Derived Peptide in Suspension-Cultured Tobacco Cells. Tomoko Kagenishi, Ken Yokawa, Masaki Kuse, Minoru Isobe, François Bouteaua, and Tomonori Kawanoa, Z. Naturforsch. 2009, 64 c, 411 – 417.

327.  Development of a new protein labeling strategy, oxidation labeling part 1: Preliminary evaluation and synthesis of tautomycin containing a metal coordinating unit. Sydnes, M. O.; Miyazaki A.; Isobe, M.; Ohinata, H.; Miyazu, M.; Takai, A. Tetrahedron, 2010, 66, 1735-1741.

328.  Synthesis of an Advanced Intermediate Bearing Two Hydroxy Groups for (-)-Tetrodotoxin and Its Analogs. Nishikawa, T.; Koide, Y.; Adachi, M.; Isobe, M.  Bull. Chem. Soc. Jpn, 2010, 83, 66-68.

329.  Synthesis of Glycocinnasperimicin D,  Nishiyama, T.; Kusumoto, Y.; Okumura, K.; Hara, K.; Kusaba, S.; Hirata, K.; Kamiya, Y.; Isobe, M.; Nakano, K.; Kotsuki, H.; Ichikawa, Y. Chem. Eur. J. 2010, 16, 600 – 610.

330.  Scalable Synthesis of a New Dihydroxylated Intermediate for Tetrodotoxin and its Analogs, Nishikawa, T.; Hiramatsu, T.; Araki, H.; Isobe, M.  Synthesis, 2010, 1992-1998.

331.  Chiral Cyclobutane Synthesis by Exploiting a Heteroatom-Directed Conjugate Addition. Tsao K-W.; Isobe, M.  Org. Lett., 2010, 12, 5338-5341.

332.  Suzuki-Miyaura Coupling for General Synthesis of Dehydrocoelenterazine applicable for 6-position Analogs directing toward Bioluminescence Studies. Phakhodee, W.; Toyoda, M.; Jhou J. M.; Khunnawutmanotham, N.; Isobe, M. Tetrahedron, 2011, 67, 1150-1157.

333.  Synthesis of bicyclo[4.2.0]octan-2-ol, a substructure of solanoelepin A. Isobe, M.; Niyomchon, S.; Cheng, C-Y.; Hasakunpaisarn, A.  Tetrahedron Lett., 2011, 52, 1847-1850.

334.  Synthetic Study on Sespendole, an Indole Sesquiterpene Alkaloid: Stereocontrolled Synthesis of the Sesquiterpene Segment Bearing All Requisite Stereogenic Centers. Sugino, K.; Nakazaki, A.; Isobe, M.; Nishikawa, T.  Synlett, 2011, 647-650.

335.  Dynamic Chirality Determines Critical Roles for Bioluminescence in Symplectin–Dehydrocoelenterazine System, Kongjinda, V.; Nakashima, Y.; Tani, N.; Kuse, M.; Nishikawa, T.; Yu, C-H.; Harada, N.; Isobe, M. Chemistry An Asian J. 2011, 6, 2080-2091.

336.  Concise Synthesis of Deformylflustrabromine, a Marine Indole Alkaloid, through a Propargyl Dicobalt Hexacarbonyl Complex Isaji, H.; Nakazaki, A.; Isobe, M.; Nishikawa, T. Chem. Lett. 2011, 40, 1079-1081.

337.  Three types of reaction of carbon nucleophile toward methoxyphenyl-acetylenic sulfones, Cheng, C-Y.; Isobe, M. Tetrahedron, 2011, 67, 9957-9965.

338.  Total Synthesis of Polygalolide A. Adachi, M.; Yamada, H.; Isobe, M.; Nishikawa, T., Org. Lett., 2011, 6532-6535.

339.  Stereocontrol with Trimethylzincate toward Gibberellin Synthesis. Isobe, M.; Chiang, C.-T.; Tsao, K.-W.; Cheng, C.-Y.; Bruening, R., Chem. A. European J., 2012, published online on March 2, 2012.


List of Review articles：(2009 ~ 2010)

26.    Medium size Ether Ring, Isobe, Minoru; Pattarawarapan, Mookda; Phakhodee, Wong; Charoonniyomporn, Sodsaporn; Hamajima, Akinari. Elegant Total Synthesis of Natural Product, Chapter 8- Wiley-VCH, MS-Submitted on Jan 19, 2009.  Invited paper but not published yet.

27.    Tautomycin’s Interactions with Protein Phosphatase 1, Sydnes, M. O.; Isobe, M. Chem. Asian J. 2010, 5, 410-420.

28.    Isobe, M.; Hamajima, A. Total Synthesis of Marine Polyether Toxins, Natural Product. Reports (RSC), 2010, 27, 1204-1226.


List of Invited Lectures：(2009 ~ 2011)

100.  Start-up Symposium of JSPS-ACP II, Chiba, Japan organized by A. Nishida, Aug, 2009.

101.  Naito Int. Conference “Chemical Biology 2”—An Emerging Field Inspired by Natural Product Chemistry”, Invited Paper; Gatoh Kingdom Sapporo, Japan 2009, Sep 8-11.

102. M. Isobe, 5th Japanese-Sino Symposium on Organic Chemistry for Young Scientists, “Stereocontrol in Synthesis of Natural Products”, Plenary Lecture, Chendu, China, October, 2009.

103. M. Isobe, Kuo-Wei Tsuao, Chia-Yi Cheng, Anuch Hasakunpaisarn, Supaporn Niyomchon, Sodsaporn Charoonniyomporn, and Kun-Hsun Huang, “Heteroconjugate Addition-based Synthesis of Natural Products”, Invited Lecture, Int. Conf. Organic Synthesis (ICOS-18), Bergen, Norway, August 2010.

104. M. Isobe, 13th Marine Natural Products, Plenary Lecture, “Marine Natural Product Synthesis with new Methodologies and Strategies for Motivation”, Phuket, Thailand, October 2010.

105.  M. Isobe, Nagoya Medal Symposium Panel Discussion: Nagoya, Japan, October 2010.

106.  M. Isobe, PreSymposium on ICCEOCA-5 Khaoshung, Taiwan, November 2010.

107. M. Isobe, Plenary Lecture “New Molecular Science from Synthetic and Bioorganic Chemistry related to Natural Products” at 14-ACC (Asian Chemical Congress): Bangkok, Thailand, September 5-8, 2011.

108. M. Isobe Start-up Symposium of Chemical Biology of Natural Products, Plenary Lecture “New Molecular Science from Synthetic and Bioorganic Chemistry related to Natural Products” at JSPS New Research Field Project, Keio University, 2011, Oct. 11.

Book Edited：
  1. 磯部　稔・西川俊夫、薬学雑誌Review「誌上シンポジウム」 多国間学術拠点形成事業「アジアの最先端有機化学」（斉藤直樹編）YAKUGAKU ZASSHI 2009, 129, 401-406.
     
  2. 下村脩著（他 共同執筆・磯部　稔・ 村上龍男・長野哲雄・大隅典子・高橋真理子）「クラゲの光に魅せられて」ノーベル化学賞の原点p89-148：朝日新聞社（ノーベル化学賞受賞記念・下村脩講演会−−−パネル討論会「光の魅力、探求する喜び」に加筆修正）2009.6.10.
     
  3. 磯部　稔・西川俊夫・市川義康「テトロドトキシンの合成 p232-234」「グリコシンアスペリミヂンの合成 p81-82」“天然物の全合成　2000-2008(日本)”分担執筆・有機合成化学協会編・化学同人　2009.6.
     
  4. 北川　勲・磯部　稔「天然物化学・生物有機化学 I　—天然物化学−」朝倉化学大系13巻369ページ（朝倉書店）2008.5.30
     
  5. 北川　勲・磯部　稔「天然物化学・生物有機化学 II　—全合成・生物有機化学−」朝倉化学大系14巻278ページ（朝倉書店）2008.6.30
     
  6. 「天然物の全合成2000-2008日本」有機合成化学協会　submitted June 2008.
     
  7. 磯部　稔・大藪　紀雄・西川　俊夫：「フグ毒テトロドトキシンの最初の不斉全合成」　有機合成化学協会誌2007 65(#5) pp492-501.
     

 

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